BROUSSOCHALCONE A IS A NOVEL INHIBITOR OF THE ORPHAN NUCLEAR RECEPTOR NR4A1 AND INDUCES APOPTOSIS IN PANCREATIC CANCER CELLS

Broussochalcone A Is a Novel Inhibitor of the Orphan Nuclear Receptor NR4A1 and Induces Apoptosis in Pancreatic Cancer Cells

The orphan nuclear receptor 4A1 (NR4A1) is overexpressed in pancreatic cancer and exhibits pro-oncogenic activity, and NR4A1 silencing and treatment Coffee Filters with its inactivators has been shown to inhibit pancreatic cancer cells and tumor growth.In this study, we identified broussochalcone A (BCA) as a new NR4A1 inhibitor and demonstrated th

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A Narrative Review with Strategic Analysis of Home Care Services for Older Adults in Seoul, South Korea: Toward a Comprehensive Care Approach

Dasom Kim,1 Hyeongsu Kim,2 Rahil Hwang,3 Sungwon Jung,4 Mi Young Kim,5 Young Ko,6 Jina Kang,7 Jinbeom Park,7 Seoyoung Yun7 1Department of Nursing, College of Health and Medical Sciences, Cheongju University, Cheongju, Republic of Korea; 2Department of Preventive Medicine, School of Medicine, KonKuk University, Seoul, Republic of Korea; 3Department

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Responsible Design - an experiment in collaboration

The imminent impact of the climate change has forced architecture schools to rethink their pedagogic structures.Using a scaffolded approach in our new MArch studio, we can demonstrate that the OATMEAL CHOCOLATE CHIP multiple narratives are required to deliver a responsive building capable of being durable, resilient and flexible.We argue that under

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Proteomic approach to understanding the maternal effect in the flesh fly, Sarcophaga bullata (Diptera: Sarcophagidae)

Progeny of the flesh fly Sarcophaga bullata exposed to short day length show a maternal effect that prevents the expression ProLogic Parts of pupal diapause.Although ecological aspects of this effect are well studied, not enough is known about the molecular mechanisms underlying this maternal effect.In this study, two-dimensional electrophoresis wa

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